Juli (Major Character)

Juliana, Kabesang Tales's daughter and Basilio's sweetheart is known by the nickname Juli. Devoted to Basilio, when her family falls into debt she decides to become a servant rather than sell the locket he had given her, once a possession of Maria Clara's that had fallen into his hands. Pure and innocent, she is nevertheless aware of the curate's reputation as a womanizer. But she is made to feel by a devout, busybody neighbor woman that she has no other recourse but to ask his help in freeing Basilio. After much hesitation she approaches the friar, only to end up getting fatally injured running from him.

Paulita Gomez (Major Character)

A beautiful girl who is admired by all the students, she at first shows preference for Isagani. But she is thrown into the company of Juanito Pelaez because her aunt, the ridiculous Doña Victorina Noli Me Tangere, has taken an interest in the young heir, even contemplating marrying him if her runaway husband were found to be dead. Eventually the self-centered Paulita chooses to marry the amusing Juanito rather than the serious Isagani. Her romantic dilemma is similar to that faced by Rizal's real-life sweetheart Leonor Rivera.

Don Custodio (Major Character)

A high official in the government, he has held many posts, many of which he had no qualifications for. He used his rich wife's money to secure such positions. He has a mistress, a dancer named Pepay, on whom people rely for assistance in swaying Don Custodio when they need a favor from him.

Padre Florentino (Major Character)

A secular Filipino priest. Pressured by his mother, he became a priest even though he was in love. After his former sweetheart married a worthless man, he devoted himself to his priestly duties and the study of natural sciences. He prefers to live alone on his family's remote seaside property than to maintain the position of curate, which suggests his strong character in avoiding the temptations of a prestigious position and high income. Through his words to the dying Simoun, he reaffirms Rizal's stance that liberation must be achieved not through bloody revolution but through peaceful reforms.

Kabesang Tales (Major Character)

Aspiring to start his own farm, he suffered great losses. First, his wife and eldest daughter died while clearing their land. Then most of his land was seized and he was charged an exorbitant tax on the little left to him. Known to be dependable, he was elected the kabesa or head of the barangay, which meant often having to appease the higher officials by shouldering the expenses of those who were unable to pay their taxes. His son was conscripted by the Civil Guard and his daughter, Juliana, became a servant to help pay off their debts. Finally, when Simoun comes to pass the night at his house, he takes Simoun's revolver and goes to join the tulisanes. He murders the friar-adminstrator and the new tenants of his land. Later Juliana is killed in an encounter with a friar and his father, struck dumb, dies in an encounter with the Guardia Civil, shot by his own grandson.

Makaraig (Major Character)

The rich student who offered his own house as the dormitory of the students studying in Ateneo Municipal de Manila. He leads the students with Isagani to set up a spanish school, but later the were defeated in the movement.

Isagani (Major Character)

The best friend of Basilio, he is a poor law student and poet. He has little fear of authority and speaks openly of his patriotic ideals, becoming the leader of a group of students who plan to set up a school for the teaching of Spanish to natives. With his idealism, he clashes with the cynical Simoun. He is in love with the spoiled, flirtatious Paulita Gomez, against the advice of his uncle and guardian Padre Florentino.